The genetics of OA are complex and considered to involve interactions between multiple genetic variants.
Burgess, S., Butterworth, A. & Thompson, S. G. Mendelian randomization analysis with multiple genetic variants using summarized data.
Genome-wide association studies have identified multiple genetic variants associated with vertical cup-to-disc ratio (VCDR).
However, the genetic architecture of ADHD is complex, with multiple genetic variants of individually small effect size contributing to disease in most patients.
Multiple genetic variants have been linked to risk of Parkinson disease (PD), but known mutations do not explain a large proportion of the total PD cases.
However, there is increasing evidence that the missing heritability in psoriasis could be explained by multiple genetic variants of low effect size from common genetic pathways.
Typically, combinatorial pharmacogenetic decision support tools use algorithms to integrate multiple genetic variants and assemble the results into an easily interpretable report to guide prescribing of antidepressants and other psychotropic medications.
Since then, Dr. Crystal and his partners in Qatar have identified multiple genetic variants in multiple genes known to play causal roles in diseases including such devastating conditions as cystic fibrosis, sickle cell anemia and muscular dystrophy.
The joint analysis of multiple genetic variants considering linkage disequilibrium (LD) and potential interactions can further enhance the discovery process, leading to the identification of new disease-susceptibility genetic variants.
Information on the degree of genetic variation in key Helicoverpa armigera nucleopolyhedrovirus (HearNPV) genes is limited as the currently used techniques lack the detection sensitivity required to identify multiple genetic variants within a baculovirus population.
Among the multiple possible explanations for the "missing" variance, joint effects of multiple genetic variants are a particularly appealing target for investigation: they are well documented in biology and can often be evaluated using existing data.
