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Multiple functional pathways are involved each of the immune response phases, and each functional pathway may contribute to several of the immune response phases.
The most apparent disturbances of multiple functional pathways other than the cell cycle, apoptosis, and P53 signal pathways include mitogen-activated protein kinase (MAPK) signaling pathway, cell adhesion junction, and melanogenesis pathways.
Because immune response phases utilize multiple functional pathways and these pathways are overlapping among phases, the genes chosen for the SNP array panel were assigned to one of the following functional pathways: Adhesion-Extravasation-Migration: adhesion molecules; chemoattractants and chemoattractant receptors; cytoskeletal rearrangement signaling, motility proteins.
Understanding the pathogenesis of sepsis has been particularly challenging as this involves multiple functional pathways, comprising hundreds of genes.
These CCN proteins are involved in multiple functional pathways, including mitogenesis, cellular adhesion, migration, cell survival, differentiation, angiogenesis, and wound healing [ 1].
Furthermore multiple functional pathways within the categories, 'Immune System' and 'Immune System Diseases' summarizing genes involved in immune response and immunological changes were also highly enriched in almost all tumor entities.
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This preferential acquisition of multiple functional traits (pathways) in P. aeruginosa strains in contrast to other pseudomonads reveals the persistent evolutionary processes undertaken to evolve as a metropolitan pathogen [ 81].
These results indicate that C. moewusii and C. reinhardtii share multiple core functional pathways.
Although four genes encoding a non-heme chloroperoxidase are present in the B. cenocepacia J2315 genome (BCAL0771, BCAM2106, BCAM2109, BCAS0079), overexpression was only observed for BCAL0771, indicating the ability of our microarray-based strategy to highlight the most active gene in Burkholderia genomes where multiple paralogous functional pathways exist [ 13].
To complete our research results, we used the well-known commercial software, Ingenuity® Pathway Analysis (IPA) and Metacore, to do multiple functional and pathway analyses.
Disease susceptibility is likely to depend on the cumulative effect of variants in multiple genes interacting in functional pathways.
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