Sentence examples for multiple endpoints of from inspiring English sources

Thus, tumors that do not depend on CDK4/6 for G1-S transition and/or can rescue CDK4/6 inhibition by the activity of other CDKs may require alternative approaches, including the use of compounds that affect cyclin D1 transcription or protein turnover and combination therapies that target multiple endpoints of cyclin D1 action simultaneously [50].

Our study is one of the first to have compared multiple endpoints of immune-mediated asthma in a large number of inbred mouse strains.

Often the advantage of a multivariate random-effects meta-analysis lies in its ability to use the between-study correlation of the multiple endpoints of interest.

Therefore, multiple endpoints of cell death and apoptosis can be measured in a single experiment with very small amounts of cells.

The same study also showed that when gefitinib was used in combination with TZ the in vivo efficacy has been improved as judged by inhibition of tumor growth, but the data obtained by measuring multiple endpoints of therapeutic activity revealed that the combination was not beneficial [ 12].

Failure to consider important outcomes can limit the validity and utility of clinical trials; specifying multiple endpoints for the evaluation of treatment efficacy, however, can increase the rate of false positive conclusions about the efficacy of a treatment.

Further, as shown in Figure 2, many of these genes are associated with outcome over multiple endpoints (nine of them across all three endpoints).

A well-designed toxicology study will include multiple endpoints indicative of biological effect on a single organ or tissue.

When multiple endpoints are of interest in evidence synthesis, a multivariate meta-analysis can jointly synthesise those endpoints and utilise their correlation.

The permutation criterion described here allows an assessment of multiple endpoints simultaneously with consideration of the direction of the treatment effect.

38 Major strengths of our study are its prospective design, relative large sample size, multiple endpoints and use of detailed information on lifestyle, anthropometric and biological variables, allowing to control for their possible confounding effect.