Sentence examples for several endpoints of from inspiring English sources
For this exercise, the typical inherent variability associated with several endpoints of testicular function in rats, rabbits and humans was established by a review of the published literature.
Based on this foundation, and the knowledge that calcium functions as a second messenger in numerous signaling pathways and – in neural cells – contributes to the excitatory state [27], the remainder of this report describes several endpoints of relevance to PD that respond to SMF in a manner similar to ZM241385 in PC12 cells.
Although we hypothesised that preventing metabolic acidosis would affect the several endpoints of VILI, we showed that correction of the acid-base balance did not affect VILI.
We chose an MV strategy that closely reflected the human setting by using clinically relevant VT, preventing shock and gross lung histopathological changes, and compared lower VT with higher VT with respect to several endpoints of VILI.
One final problem may be that infusion of saline solution to correct for low arterial blood pressures leads to metabolic acidosis in models of VILI [ 12, 13], although metabolic acidosis may influence several endpoints of VILI [ 14, 15].
As a result, a quadratic relationship was considered in specific statistical tests that supported the significance of several endpoints for some POP exposures.
High PTX3 values were associated with several endpoints indicative of severe disease (Table 3).
Nevertheless, there was little suggestion of efficacy against any of several endpoints no matter what sort of analysis was conducted.
These inconsistencies could be a result of the heterogeneity of treatment modalities, the heterogeneity of tumour sites, the use of several endpoints (i.e. LC, LRF, DFS or OS), the use of various SUVMAX cut-off values, and the use of either the SUVMAX of the primary tumour or the SUVMAX of a metastatic lymph node.
Previous dose range-finding studies with nonylphenol (NP) administered to rats in a soy- and alfalfa-free diet showed apparent feminization of several endpoints in male rats at doses of 25 ppm and above.
Consequently, multiple statistical testing of several endpoints without or with only insufficient adjustment of the chosen significance level, or the use of inadequate statistical methods [21, 69 71].
