Sentence examples for multiple deleterious mutations from inspiring English sources

The role of recombination in bringing together either multiple beneficial or multiple deleterious mutations (in the language of population genetics, the dissolution of negative linkage disequilibrium) lies at the core of modern models of recombination and selection.

The collective effect of fixing multiple deleterious mutations can drastically reduce the mean fitness of a population, particularly if the mutations interact in a negatively synergistic fashion [8], [10], [11].

To test this hypothesis, laboratory populations of E. coli with experimentally accumulated multiple deleterious mutations were used.

Inbreeding depression is caused by increased homozygosity for a single locus with heterozygous advantages and/or a single or multiple deleterious mutations with recessive effects (reviewed in Charlesworth and Willis 2009).

By contrast, if deleterious mutations interact so that their combined effect is smaller than expected under the multiplicative model, then epistasis is called antagonistic (or positive in the terminology of Phillips et al).. Antagonistic epistasis therefore implies unexpected robustness to the effects of multiple deleterious mutations [ 2].

For the remaining probands, multiple homozygous mutations in genes in hearing-relevant pathways and multiple heterozygous deleterious mutations were present.

In the case of a fitness cost of resistance, the sequential acquisition of multiple deleterious resistance mutations should result in a cumulative fitness deficit that may reduce the likelihood that a strain will evolve extensive drug resistance.

The figures would possibly be slightly different if one considered the additive effect of multiples recessive deleterious mutations affecting different genes, each with lower allelic frequencies, and clearly different with different mutation rates.

Here, we develop a comprehensive model of adaptive evolution in linked genomes, which integrates interference interactions between multiple beneficial and deleterious mutations into a unified framework.

Multiple factors, including deleterious mutations [ 2- 4], adaptation events [ 5- 7], parasites [ 8, 9], and combinations of the above [ 10- 12] were suggested to explain the benefits of sex against complete asexuality.

We study the evolution of the rate of self-fertilization in response to deleterious mutations at multiple loci.