Sentence examples for multiple deleterious alleles from inspiring English sources

It is necessary, therefore, to invoke the 'common-disease common-variant' (CD-CV) model [ 3], which assumes an accumulation of risk caused by the carriage of multiple deleterious alleles, to explain current experimental findings.

Furthermore, we studied the relation between SEMs and age-dependent skewing of X chromosome inactivation that represents a phenomenon favoring the expression of multiple deleterious alleles and consequently influencing human health [ 26].

It is believed that inbreeding depression is due to the expression of multiple deleterious recessive alleles, as a result of increased homozygosity.

By assessing all populations, 20,296 (61%) genes with multiple independent potentially deleterious alleles were identified, of which 13,119 (40%) genes possessed multiple alleles with interrupted exon sequences.

However, strong ID may be maintained despite high selfing rates if there are mildly deleterious alleles at multiple loci [ 21, 66, 67].

The most powerful approach to associate a particular gene with an ultra-rare disease is to identify multiple unrelated individuals with the disorder whose genomes harbor deleterious alleles in a shared gene, regulatory element or pathway (Schuurs-Hoeijmakers et al., 2012).

We compared the ratio of deleterious alleles with the total number of alleles at the deleterious-allele loci genotyped between case children and comparison participants.

Superimposing these data with resequencing revealed CNVs to (1) be sufficient to cause disease, (2) Mendelize heterozygous deleterious alleles, and (3) contribute oligogenic alleles by combining point mutations and exonic CNVs in multiple genes.

But recessive deleterious alleles are "hidden" from natural selection by their dominant non-deleterious counterparts.

"Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck". PLoS Genetics 11 (8): e1105436.

Kiezun, A. et al. Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.