Sentence examples for many deleterious mutations from inspiring English sources
Based on early estimates of the mutation rate in humans and the size of the human genome, simple calculations done decades ago showed that only a small fraction of it could be constrained at the sequence level, otherwise there would be too many deleterious mutations in every generation for the species to survive (Ohno 1972).
Part of the difficulty is that ERVs may be several 100 million years old [4] and have accumulated many deleterious mutations.
As an example, the first subfamily highlights another important factor, represented by the "modif_charge" predicate, which characterizes many deleterious mutations.
Such speciation events can only be successful if the newly arising species has not accumulated too many deleterious mutations during its hybridogenetic history.
Populations at risk may decline to census sizes so low that many deleterious mutations can be no longer be filtered out by selection.
As a result, cultivars are highly heterozygous and carry many deleterious recessive mutations [5].
Among the findings, the study reports that when compared with protein coding genes, binding site DNA shows close to three times as many "weakly deleterious mutations," that is, mutations that may weaken or make an individual more susceptible to disease, but are generally not severe.
Indeed, while some genes accumulate many potentially deleterious mutations, no mutations have been found in others.
In conclusion, we find that fitness decays in recurrently bottlenecked populations of hypermutator P. aeruginosa because of the fixation of many weakly deleterious mutations and a few highly deleterious mutations.
Despite differences in approach, it becomes clear that HLOF variants are relatively common amongst healthy individuals, with each individual carrying about 10 20 HLOFs, and many seemingly deleterious mutations can be tolerated.
As a bonus, with gametophytic selection acting on the haploid phase of the life cycle, many highly deleterious mutations are eliminated from the plant gene pool, curtailing an increase in genetic load.
