Sentence examples for several deleterious mutations from inspiring English sources

Possibly, the allelic form of ABZ1 has accumulated several deleterious mutations leading to a loss of activity.

TPO functional defects are strongly associated with TIOD and several deleterious mutations within this catalytic region have been reported [ 44, 53- 55].

The authors introduced several deleterious mutations one by one into the genome of DNA bacteriophage φX174 and then selected the mutant genomes on the Escherichia coli host to recover fitness.

In this taxon, the single example of KLK2 loss by deletion was found in Aotus nancymaae, whereas several deleterious mutations were detected in Callicebus moloch, Callithrix jacchus, and Saguinus oedipus.

The experimental strategy in Figure 1 also offers the possibility of determining how epistatically interacting mutations were actually fixed for example through sequential functional intermediates as posited by Maynard Smith, or by the simultaneous or closely coupled fixation of several individually deleterious mutations (Kimura, 1985; Meer et al., 2010).

Annotation on databases of genetic variation and human disease mutations revealed several novel, potentially deleterious mutations.

We verified the presence of the candidate compensatory residues in several lineages without the deleterious mutations, but the opposite was never observed.

Furthermore, several SAMP strains had deleterious mutations in the genes associated with hereditary diseases (e.g., Prx p.R167C, Ldb3 p.R473W and Gja3 p.S405P), which mutations have not been previously reported to occur in SAMP strains.

Interestingly, we detected deleterious mutations in several genes that had been earlier reported to be associated with severe genetic disorders in both humans and mice.

The clinical relevance of c.8488-1G > A has been discussed above and that of c.212+1G > A is strongly supported by family, bioinformatics (donor site disruption) and functional data as well as by the fact that other variants of the donor site of exon5/intron 5 (c.211A > G and c.212+3A > G) were definitely classified as deleterious mutations by several approaches [ 19, 50, 51].

In addition to the clearly deleterious mutations, we identified several missense variants; 13 of these are predicted deleterious by a consensus of six in silico tools (Supplementary Table S2).