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Using a repeated measures design, change in carnitine levels and change in fatigue in childhood cancer patients receiving ifosfamide, cisplatin, or doxorubicin were examined over multiple chemotherapy cycles.
These efficacy results provide evidence of the benefits of the preservation of excellent emetic control over multiple chemotherapy cycles with the new antiemetic combination, NEPA.
Finally, we examined only one cycle of chemotherapy, and the cost-effectiveness of the aprepitant regimen over multiple chemotherapy cycles is uncertain.
In this study, benefilgrastim administered once per cycle at 240 or 320 µg/kg SC provided neutrophil support with a safety profile similar to that of pegfilgrastim during multiple chemotherapy cycles.
Of particular concern is the development of anticipatory nausea and vomiting, a conditioned response that is difficult to treat, and the gradual resistance to anti-emetic therapy after multiple chemotherapy cycles [ 35].
Similar(55)
The RMS4.99 study was designed to explore the role of multiple sequential high-dose chemotherapy cycles administered early in the treatment of children with metastatic rhabdomyosarcoma.
The divergent outcomes are ascribed to multiple factors, such as histological subtypes, chemotherapy schemes, chemotherapy cycles, tumor grade, and so on.
Further study is required to evaluate the use of aprepitant in the UK for preventing CINV associated with MEC over multiple cycles and in patients who experienced CINV in previous chemotherapy cycles.
The efficacy of NACT was similar between single-and multiple-agent chemotherapy, BIP and non-BIP regimen chemotherapy, or various chemotherapy cycles.
The multiple cycle safety Study 3 also assessed efficacy over cycles [ 35]. 1033 NEPA-treated patients participated in 4428 total chemotherapy cycles in these two trials; 75% of patients completed at least 4 cycles.
This study including 413 patients receiving 1961 chemotherapy cycles offers compelling evidence of the continuous safety of NEPA and support for its efficacy in patients receiving multiple cycles of either MEC or HEC.
Related(14)
multiple chemotherapy courses
several chemotherapy cycles
various chemotherapy cycles
multiple wash cycles
multiple chemotherapy regimens
multiple treatment cycles
multiple chemotherapy lines
multiple chemotherapy agents
multiple chemotherapy regimes
multiple sampling cycles
multiple chemotherapy treatments
multiple chemotherapy drugs
multiple chemotherapy toxicities
multiple chemotherapy subgroups
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