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The sequential use of multiple chemotherapy regimes, if tolerated, can allow survival <24 months.
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Multiple chemotherapy regimens have been associated with interstitial nephritis, most notably ipilimumab.
Median survival is now of the order of 20 22 months in patients who receive biological agents and multiple sequential chemotherapy regimes [ 65].
Median survival following systemic treatment is now of the order of 20 22 months in patients who receive biological agents and multiple sequential chemotherapy regimes, 5-year survival remains close to 0%%.
Increased use of multiple-agent chemotherapy regimes for these tumours in the 1970s may have contributed to these increases in excess risk.
Jo Symons took the Agendia test, but not before being treated with two different chemotherapy regimes, both unsuccessful.
There are now several chemotherapy regimes that impact survival.
Patients on high dose chemotherapy regimes were excluded.
55.3% of patients received one chemotherapy regimen, 13.2% had two and 6.6% had three or more chemotherapy regimes.
VZV-specific T-cell responses also did not significantly differ between patients on different chemotherapy regimes.
As the scope of this study spans from 1983 to 2002, chemotherapy regimes changed over this time.
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