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A key principle of using multiple chemotherapy agents at once is to go after cancer cells by several different routes to reduce the chance that they will become resistant.
Multiple chemotherapy agents are responsible for CNS complications.
Most other studies reporting rates of neutropenia after IP chemotherapy included treatment with multiple chemotherapy agents with varying toxicity profiles and/or nonhyperthermic IP chemoperfusions.
Bcl-2 and Bcl-XL appear to function in the same apoptotic pathway [ 7], and both confer resistance to multiple chemotherapy agents when tested in experimental systems.
These findings corroborate those from Giordano et al. [ 13], who observed a decrease of vWF antigen levels after multiple chemotherapy agents, including prednisone, in children with acute lymphocytic leukemia.
However, these drugs do not play well with the multiple chemotherapy agents used for colorectal cancer therapy and drug interactions continue to plague such combination regimens in the practice.
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60 Biochemotherapy, a combination of multiple cytotoxic chemotherapy agents with immune modulators, was developed to overcome the relative treatment resistance of metastatic melanoma.
This Phase II study demonstrated that single-agent carfilzomib can induce durable responses in heavily pretreated multiple myeloma patients who had failed multiple chemotherapy regimens, including those containing bortezomib and immunomodulatory agents.
Furthermore, LC-CD133+, unlike LC-CD133−, highly co-expressed the multiple drug-resistant marker ABCG2 and showed significant resistance to chemotherapy agents (i.e., cisplatin, etoposide, doxorubicin, and paclitaxel) and radiotherapy.
In lung cancer-derived CD133-positive cells (LC-CD133, higher Oct-4 expression coexpressed the multiple drug-resistant marker ABCG2 and showed significant resistance to chemotherapy agents and radiotherapy.
Zhang et al. have incorporated a leukemia cell-binding aptamer into a Poly-Aptamer-Drug (PAD) system, which is composed of multiple aptamer units synthesized by rolling circle amplification and physically intercalated chemotherapy agents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com