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Finally, since 28 of 49 BC metastases were necropsy-derived compared to none of the CRC liver metastases, which were usually resected together with the primary colorectal tumour, it might be that advanced stage and multiple chemotherapy courses have influenced the growth pattern of BC metastases.
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Nomograms, which integrate clinical and pathological variables including tumor receptors and number of chemotherapy courses using multiple logistic regression model, have been developed to predict complete pathological response on the basis of preoperative treatment [ 18- 20].
Extra-haematological toxicities reported in this study of multiple cycles of high-dose chemotherapy courses were found to be different from the toxicity profile of single very high-dose treatments using the same drugs (Kennedy et al, 1991; Eder et al, 1990; Wolff et al, 1990; Vahdat et al, 1995).
The number of chemotherapy courses was recorded accordingly.
The median number of chemotherapy courses was 4.
A total of 1299 chemotherapy courses were administered.
There were 3223 chemotherapy courses given to 1116 patients.
The median number of i.p. chemotherapy courses was 3 (1–8).
In the treatment arms, 75.5% (chemotherapy alone) and 77.7% (chemoradiation) completed all four chemotherapy courses.
I'm five craniotomies in, plus weeks and weeks of radiation, multiple chemotherapies and, most recently, "alternative approaches".
Each chemotherapy course may include several cycles.
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