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4) It is well established that E. coli SSB can bind single stranded DNA in multiple binding modes that differ in the extent of wrapping of the ssDNA around the tetramer.
The structure activity relationships were discussed and their multiple binding modes were further clarified in the molecular docking studies.
As reported in earlier papers, our modeling has produced very effective algorithms to predict drug-binding affinities and to predict multiple binding modes [24].
Crystal structures for these compounds bound to toxin B pentamer revealed a conserved binding mode for the MNPG moiety, with multiple binding modes adopted by the attached morpholine derivatives.
Kinetic experiments show the multiple binding modes of HD1 and NU172, which both interact with multiple sites of thrombin with low nanomolar affinities and show little specificity of interaction for prothrombin vs. thrombin.
The observation that monoclonal antibodies can use multiple binding modes is intriguing.
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Considering that in the actual substrate, the D-amino acid would be linked to the tRNA, a multiple binding mode is highly improbable as the orientation and position of the D-amino acid would be fixed by the binding of terminal adenosine.
Assuming that our measurements on two sets of distinct di- and tri-peptides reflect the stoichiometries in general, our new data add to our previous multiple binding mode model by showing that tri-peptides are transported using three protons, whereas di-peptides are transported using four or possibly even five protons per cycle.
For every TF with motif information, we selected a representative motif, or motifs if that TF appears to have multiple-binding modes (e.g., multimers), using the following scheme.
Our medicinal chemistry strategy was based on an in-house Met-focused library of aminoacid-amide derivatives enriched through structure-based computer modeling, taking into account the Met multiple-binding-mode feature.
Considering multiple ligand binding modes is of potential relevance to studying ligand recognition, but is generally ignored by currently available techniques.
Related(20)
multiple binding modalities
multiple binding mechanisms
various binding modes
frequent binding modes
multiple binding modules
multiple binding model
multiple binding caches
multiple binding components
multiple binding keys
multiple failure modes
multiple binding orientations
multiple oscillatory modes
multiple binding experiments
multiple operating modes
multiple binding specificities
multiple binding motifs
multiple binding registers
multiple binding events
multiple binding domains
multiple binding partners
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