Sentence examples for multiple binding specificities from inspiring English sources

Furthermore, DARPins can be engineered to carry various effector functions or combine multiple binding specificities, enabling completely new drug formats.

The p53 C-terminus and 14-3-3 14-3-3 14-3-3 disorder differently with regard to enabling museintrinsicing specificities.

It is therefore reasonable to think of even more complicated experiments, aiming to discover multiple binding specificities of protein complexes or even whole mixtures of proteins at once.

They possess multiple binding specificity and they are able to participate in one-to-many and many-to-one interactions [ 73].

Differential expression of multiple isoforms with different binding specificities produces a "neural code" of downstream gene expression, in which phenotypes can be specified by either a single isoform or a combination of isoforms.

It has been observed that some Sec24 paralogs have multiple binding sites each with specificity for some sorting signals or cargoes (Miller et al. 2003; Mossessova et al. 2003; Wendeler et al. 2007; Sucic et al. 2011), suggesting that the cargo specificity of Sec24 paralogs evolved early on in the eukaryotic lineage.

According to Sickmeier et al. [ 85], they also play various roles in signaling and regulation by multiple binding of proteins and high-specificity low affinity interactions.

Many different engineered formats for the antibody molecule and multiple methods for raising and tailoring binding specificities are currently available.

In order to test the transferability of the prediction method to different MHC proteins, we trained the scoring method on binding data for DRB1*0101 and used it to make predictions for multiple MHC allotypes with distinct peptide binding specificities including representatives from the other human class II MHC loci, HLA-DP and HLA-DQ, as well as for two murine allotypes.

Interestingly, the promoter region of the hERG gene harbors multiple binding sites for oncoproteins, such as specificity protein 1 and nuclear factor kappa light chain enhancer of activated B-cells, and for the tumor suppressor protein Nkx3.1 (Nk3 homeobox 1).

The presence of multiple binding sites in HOMRE can influence DNA-binding specificity by facilitating cooperative homeotic protein interactions.