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The PDZ domain is one of the most ubiquitous protein domains that is involved in coordinating signaling complex formation and protein networking by reversibly interacting with multiple binding partners.
These motions are directly relevant in the context of ubiquitin's ability to recognize multiple binding partners.
Mutations in filamin A (FLNa), an essential cytoskeletal protein with multiple binding partners, cause developmental anomalies in humans.
We suggest that local disorder is a property typical of coiled coil binding sites and proteins that have multiple binding partners, of which tropomyosin is one type.
It is possible that this property is typical of proteins that have multiple binding partners, i.e. signaling molecules, of which tropomyosin is one type.
The flexibility that disorder imparts allows these proteins to have multiple binding partners as well as multiple functions based upon confirmation.
Similar(26)
By virtue of their structural malleability and propensity to interact with multiple-binding partners, these peptide stretches of ∼30 or more amino acid residues have become increasingly recognized for their pivotal and prevalent role in cellular functions including many implicated in human disease pathogenesis (Babu et al., 2011).
These results identifying cell-type-specific functions and multiple presynaptic binding partners for different LRRTM family members reveal an unexpected complexity in the design and function of synapse-organizing proteins.
RACK1 has multiple protein binding partners and affects a variety of cellular functions.
The outcome of the reuse of the binding pocket by multiple distinct binding partners and the required complementarity between binding peptide and the binding pocket results in the repeated patterns that we refer to as motifs.
In this study the effect of a multiple peptide binding partner to the receptor binding site of HA could be determined with surface plasmon resonance measurements.
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