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Total plasma cholesterol was elevated in both mouse strains fed HFD but was slightly lower in the OPN KO mice.
We observed significant differences in clamp data from the mouse strains fed either diet, reflecting greater insulin sensitivity in the OPN KO mice (Figure 2A C).
However, both mouse strains fed Western diet had a significantly greater volume of fat vesicles than the control groups.
The results suggest that the different levels of hepatomegaly observed in the two mouse strains fed Western diet is due to AHR-dependent differential fat accumulation in hepatocytes.
This reduction is lower than the drop reported in other mouse strains fed with a vitamin A-deficient diet, SENCAR mice [ 30], aryl hydrocarbon receptor- (AHR-) null mice [ 31], and BALB/c mice [ 32].
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Male mice of corresponding strains fed 0.1 ml of distilled water served as controls.
The two mouse strains were fed either a low-fat (regular) diet or a high-fat (Western) diet.
Two different mouse strains were fed with high-or low-fat diets, and compared with control mice and models in which diabetes was induced using streptozotocin (STZ).
Here we examine IR and related traits in a diverse population of more than 100 unique male and female inbred mouse strains after feeding a diet rich in fat and refined carbohydrates.
These studies suggest that neuronal loss may vary according to the different levels of lipids in the diets, different intestinal segments, mouse strains, and feeding periods.
To identify genetic and environmental factors contributing to the pathogenesis of non-alcoholic fatty liver disease, we examined liver steatosis and related clinical and molecular traits in more than 100 unique inbred mouse strains, which were fed a diet rich in fat and carbohydrates.
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