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In several mouse strains bred to produce excessive amyloid, a protein that forms plaques in the brains of people with Alzheimer's, abnormally high levels of C1q set off a microglial feast, which destroyed functional synapses long before plaque formation and symptoms of cognitive impairment set in.
All transgenic mouse strains bred normally.
Image: © Jim Frazier Rick Woychik, deputy director of the NIEHS and prior president of The Jackson Laboratory, points out that in just 10 20 generations, mouse strains bred for specific research purposes can evolve genetic differences that may affect how they respond to environmental chemicals and pharmaceuticals.
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It was thus concluded that the two C57BL/6 mice strains bred separately had stable, but different microbiota that were vertically transmitted.
We used 2- to 3-mo-old CBA/Lac and NOD/SKID mice strain bred in the SPF-animal facility at the Institute of Cytology and Genetics, SB RAS.
The mouse strains were bred and used in the animal facility of the Section for Medical Inflammation Research Universityy of Lund, Lund, Sweden).
As a result, when two animals from the same RI mouse strain are bred, their offspring will have the exact same genetic makeup (i.e., genotype) as the parents.
All mice strains were bred and maintained in the C57/Bl6 background (same colony) for over 20 generations in the animal facilities of the Biomedical Sciences Research Center "Alexander Fleming" under specific pathogen-free conditions, in compliance with the Declaration of Helsinki principles.
If these mice, from a strain bred to be particularly susceptible to atherosclerosis, were treated with THC, they showed much lower levels of the condition than did untreated mice from the same strain.
All mouse strains employed were bred in the animal facilities of the Bernhard-Nocht-Institute for tropical medicine or in the university hospital Hamburg-Eppendorf (Hamburg, Germany) which are registered by the Federal Health Authorities of the State of Hamburg.
Laboratory mouse strains are frequently bred to display specific immunity or disease phenotypes and this may in part explain the GO term enrichment across the classical laboratory mouse strains for immunity-related terms [ 46].
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