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A recent study, in fact, evaluated 42 inbred mouse strains provided an atherogenic diet for 18 weeks, and showed that DBA mice gained more body weight than any other strain [53], [54].
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Improved transgenic mouse strains provide a powerful technology platform for creating human therapeutics in the future.
Also, the accumulating reports on hair phenotypes of mouse strains provide important pointers to better understand the molecular mechanisms underlying human hair growth disorders.
Novel transgenic mouse strains provide a powerful technology platform for creating fully human monoclonal antibodies as therapeutics; ten such antibodies have entered clinical trials since 1998 and more are in preclinical testing.
To understand such genotype-by-environment interactions, the diversity of existing mouse strains provides a valuable research tool [49].
QTL analyses of crosses between other susceptible and resistant mouse strains provide additional evidence for the importance of multiple genes in P. berghei infection [15], [16], [17], [18].
This approach that exploits highly diverse mouse strains provides an efficient and effective translational bridge to study the etiology of human developmental disorders, such as autism and schizophrenia.
Highly fecund mouse strains provide an ideal model to understand the factors affecting maternal performance.
Both mouse strains provide adequate models for the study of perinatal exposure to xenoestrogens.
Four recently discovered mouse strains provide opportunities to decipher mechanisms upstream of synoviocyte activation.
These inbred mouse strains provide good platforms for studying the immune system and modeling human immune disease [ 2– 4].
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