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This study was designed to assess if T, B and natural killer (NK) cells are involved in the progress of NAFLD in mouse models after chronic fructose treatment.

This has been corroborated by observations in mouse models after deletion of apoptosis-regulating genes [13], [14].

Antibody-based DC targeting has recently been shown to be exceptionally efficient in mouse models after a single vaccination (for review see [28]).

We also were able to show, in vivo, recovery of memory impairment in SD, Aβ and KA mouse models after treatment with dietary EH-201.

There are five factors that can contribute to the pathology of cGvHD in humans and mouse models after HSCT: cytokine-mediated fibrosis, defective negative selection of T cells, deficiency of TReg cells, genetic polymorphisms and dysregulated B-cell responses.

This phenomenon has also been observed in wild-type mice or transgenic APP mouse models after treatment with classical γ-secretase inhibitors [ 8, 40] or after inactivation of PSEN1 [ 51].

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Importantly, MPC/Ad-SS-PEG was also able to efficiently mediate tumor-targeted gene delivery in the tumor-bearing mouse model after systemic injection in vivo.

The present study aims to further clarify the effect of NAPA in counteracting OA progression, in an in vivo mouse model after destabilization of the medial meniscus (DMM).

Experiments in vivo showed that compounds 10, 14, and 17 had blood glucose lowering effect in diabetic db/db mouse model after two weeks oral dosing.

The findings were in good agreement with the values (~0.94) obtained in biodistribution studies performed in the same tumor mouse model after injection of the same molar amount of 177Lu-DOTANOC (Table 3).

By following the PC-3 tumor growth in mouse model after intravenous administration of GO-DEN(Gd-DTPA -mAb/DOX, it is demonstrated that Gd-DTPA -mAb/DOXmAb can tarGd-DTPA -mAb/DOXantitancer drugs to malisnant prostate tumors andemonstratedmor growthat

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