Sentence examples for mouse model supports from inspiring English sources

One report in a mouse model supports the findings of our study.

Interestingly, a recent experimental mouse model supports the efficacy of CD4+ T-helper lymphocytes in adoptive immunotherapy.

It is particularly important that C/OTg mouse model supports persistent levels of viremia for HCVcc of different genotypes and primary isolates from chronic hepatitis C patients.

The SIRT1 knockout mouse model supports a tumor suppressor function for SIRT1, and, similar to other suppressor genes, SIRT1 is activated under cellular stress conditions, such as nutrient deprivation.

Conclusion: The Slc10a1-knockout mouse model supports the central role of NTCP in hepatic uptake of conjugated BAs and hepatitis B virus preS1/Myrcludex B binding in vivo; the NTCP-independent hepatic BA uptake machinery maintains a (slower) enterohepatic circulation of BAs, although it is occasionally insufficient to clear BAs from the circulation.

This combination caused marked in vivo tumor regressions in KRAS mutant xenografts and in a genetically engineered KRAS-driven lung cancer mouse model, supporting combined BCL-XL/MEK inhibition as a potential therapeutic approach for KRAS mutant cancers.

Remarkably, the key areas differentially activated after OA exposure in the HAB vs. LAB rat lines [13] could be confirmed in this corresponding mouse model, supporting the notion that the altered brain activation pattern in HAB animals may be a generalized feature, being indeed characteristic of enhanced trait anxiety.

In this study we have also confirmed that FoxP3+ Treg-cells are highly accumulated in the microenvironment in CRC mouse model, supporting the notion that the presence of Treg-cells may allow the escape of tumor cells from immune surveillance by cytotoxic T lymphocytes in CRC patients.

Our findings of apoptosis in the fibrocytes of the spiral ligament and a breakdown of the blood-labyrinth barrier as pathological mechanisms of the hearing loss in the malaria mouse model support this hypothesis.

Yang et al. 15, 17 previously described a mouse model supporting HBV gene expression and replication in the liver of NOD/SCID mice through hydrodynamic injection, which introduced an 1.3-fold HBV DNA (pTmcs-HBV1.3) and Sleeping Beauty transposase (pCMV-SB) into the tail vein of mice.

Our studies using an SCA2 mouse model support this notion and show that the earliest changes in motor behavior are paralleled by changes in gene expression and PC firing, whereas reductions in molecular layer thickness and PC number follow much later.