Sentence examples for mouse model supporting from inspiring English sources

This work shows that dampening neurodegenerative microglial activation via TREM2 deletion reduces neurodegeneration at an advanced disease stage in a tauopathy mouse model, supporting a role of microglia in modulating neurodegeneration.

This combination caused marked in vivo tumor regressions in KRAS mutant xenografts and in a genetically engineered KRAS-driven lung cancer mouse model, supporting combined BCL-XL/MEK inhibition as a potential therapeutic approach for KRAS mutant cancers.

Remarkably, the key areas differentially activated after OA exposure in the HAB vs. LAB rat lines [13] could be confirmed in this corresponding mouse model, supporting the notion that the altered brain activation pattern in HAB animals may be a generalized feature, being indeed characteristic of enhanced trait anxiety.

In this study we have also confirmed that FoxP3+ Treg-cells are highly accumulated in the microenvironment in CRC mouse model, supporting the notion that the presence of Treg-cells may allow the escape of tumor cells from immune surveillance by cytotoxic T lymphocytes in CRC patients.

These studies showed that ATAP-iRGD had similar tumor suppression effects to those of BH3-iRGD peptide (equal molar concentration), thus indicating ATAP-iRGD suppresses esophageal tumor growth with limited off-target toxicity in the mouse model (Supporting Information, Figure S11).

Yang et al. 15, 17 previously described a mouse model supporting HBV gene expression and replication in the liver of NOD/SCID mice through hydrodynamic injection, which introduced an 1.3-fold HBV DNA (pTmcs-HBV1.3) and Sleeping Beauty transposase (pCMV-SB) into the tail vein of mice.

"The project is to check their efficacy and understand the dosing, timing and so forth all the details of treatment using a mouse model". Support from Daedalus, she says, "is absolutely essential, because the usual funding agencies, like the NIH, do not support this kind of high-risk applied research.

One report in a mouse model supports the findings of our study.

Interestingly, a recent experimental mouse model supports the efficacy of CD4+ T-helper lymphocytes in adoptive immunotherapy.

It is particularly important that C/OTg mouse model supports persistent levels of viremia for HCVcc of different genotypes and primary isolates from chronic hepatitis C patients.

The SIRT1 knockout mouse model supports a tumor suppressor function for SIRT1, and, similar to other suppressor genes, SIRT1 is activated under cellular stress conditions, such as nutrient deprivation.