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Although the promising results of SRT2104 in an HD mouse model encourage us to further pursue treatment strategy in this direction, we need to mention that the drugs targeting SIRT1 for clinical use are still in their infancy.
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Thus, future experimental studies on alternative animal models (non-human primates and other mouse models) are encouraged and urgently necessary to better understand the pathological processes underlying human infection [ 49].
Although some early research in mouse models has been encouraging, major obstacles remain for neural stem cell (NSC) transplantation therapy.
They are now assessing the effectiveness of chemotherapy drugs on glioblastomas in mouse models; preliminary results are encouraging.
2. Generation of a knock-in mutant HexB mouse model with Eric Sjoberg, Phd, OrPhi Therapeutics.
Encouraged by the activation and inhibition of TG2 in the fibroblast wounding model, we evaluated a mouse model of small intestinal wounding to determine whether TG2 would be activated following chemically induced tissue damage.
A mouse model of familial hypertrophic cardiomyopathy.
Taube, S. et al. A mouse model for human norovirus.
(A) The KA mouse model of chronic epilepsy.
Murphy, A.M. et al. Transgenic mouse model of stunned myocardium.
Executive functions in the heterozygous reeler mouse model of schizophrenia.
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