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First dual images on healthy animal in vivo data in a mouse model show both MR and PET localization of probe within the kidneys since the elimination was renal.
Our experiments in the SCARKO mouse model show unequivocally that an active AR in SC is mandatory for timely and complete barrier formation.
Published studies with mouse model show that cumulus cells play an important role in nutritional support of the developing oocyte in the form of pyruvate [14], [15], [16] and stimulation of this nutritional support of cumulus cells is in turn dependent upon the presence of paracrine factors secreted by the oocytes [17].
However, recent experiments in a tumorigenic mouse model show that self-inactivating lentiviral vectors have low genotoxicity compared to LTR-driven MLV vectors suggesting an enhanced safety profile of such lentiviral vectors[ 40].
However, primary embryonic fibroblasts from a Recql1-null mouse model show increased aneuploidy, spontaneous chromosomal breakage and elevated sister chromosome exchanges, indicating that Recql1 is required for genome stability.
In contrast to the watermaze studies, studies in the 3xTg mouse model show impaired working memory in the Y-maze following gonadectomy [ 162, 163] – an effect that is reversed by estradiol [ 162- 164] but not progesterone replacement [ 163, 164].
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In addition, MRI and photothermal effect for mouse model showed enhanced T1 signal and temperature elevation in tumor site with photoirradiation.
In vivo implantation of the LZ scaffolds in a mouse model showed absence of foreign body reaction to the scaffold.
In vivo efficacy tests in a mouse model showed compounds 66 and 72 to be promising candidates as they exhibited significant parasitemia reductions of 96.4% and 80.4%, respectively.
Analysis of one of these mutants in a psoriasis mouse model showed its efficacy in promoting the recovery of psoriasis plaques.
A dominant-negative Gjb2 R75W transgenic mouse model shows incomplete development of the cochlear supporting cells, resulting in profound deafness from birth [Inoshita A et al. (2008) Neuroscience 156:1569–1567].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com