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One of the most striking phenotypes was the drastically increased number of fibers that failed to cross the chiasm and projected ipsilaterally (arrow in Figure 7B).
Tissue specific or constitutive deletion of these integrin chains revealed their crucial roles in skin development and homeostasis with the most striking phenotypes observed upon deletion of the β1 integrins and the hemidesmosomal α6β4 integrins [4] [7].
Hair pigmentation is one of the most striking phenotypes in humans.
Box 2. Premature greying syndromes Hair pigmentation is one of the most striking phenotypes in humans.
As one of the most striking phenotypes of Asah1P361R/P361R mice was the widespread macrophage infiltration, sera from WT, heterozygous, and Asah1P361R/P361R mice at 7 9 weeks were examined for levels of various cytokines (Fig 6A).
To test whether this synthetic defect was due to the role of Rpn13 as an Ub receptor, the five rpn1 mutants showing the most striking phenotypes were introduced by plasmid shuffle into an rpn13-KKD strain that contains a triple point mutation that inactivates the ubiquitin binding domain [ 7].
Similar(54)
Importantly, the most striking phenotype in female Rpn13−/− mice was a developmental defect in the ovaries.
However, the most striking phenotype of these flies is reduced neural inertia (Figure 6A B).
In this study, the most striking phenotype of Rest mutant ES cells is their defective adhesion, especially on a glass surface.
However, their most striking phenotype is a dramatic increase in neural inertia, due to a profoundly altered threshold for emergence (Figure 5A).
The most striking phenotype was an increase in IFE proliferation.
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