Because some proteins can give rise to more than one phenotype, rather than the most likely phenotype, a series of candidate phenotypes are predicted for each protein.
Instead of only the most likely phenotype, a series of possible phenotypes for the query protein were generated and ranked acording to the tethering potential score.
Theoretically, in a given environment, the mapping between any particular genotype and a set of phenotypes is determined by a probability function, which represents a collection of possible phenotypes around the most-likely phenotype for any given genotype [22].
Several recent studies have focused on the subset of nsSNPs that most likely influence phenotype [ 9- 13].
Several recent studies have attempted to focus on the subset of nsSNPs that most likely influence phenotype [ 2- 6].
Telomere-DSB fusion would be the most likely expected phenotype resulting from rapid, transient and only partial reduction of DNA-PKcs, as these events require only one uncapped telomere (not two as for telomere-telomere fusion).
An increased variability of mRNA abundance in Pax6+/− lens originates most likely from variable phenotypes of individual mutant lenses [21], [23].
We found that, as expected, genes listed by multiple sources as disease-associated (the 'Intersection' genes, Methods, Fig. 3A and Additional File 2) are the most likely to cause disease-like phenotypes upon perturbation, much more likely than the unfiltered genes in GAD or OMIM, according to the disease phenotype probabilities predicted from the MGI phenotypes (Fig. 3A and 3B).
The lack of immuno-detectable PG in 'Scifresh' most likely strengthened this phenotype.
These findings indicate that WCH is not a benign situation in type 2 diabetic patients and most likely represents a phenotype intermediary between normotension and hypertension.
