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Signalling through NMDA receptors can activate the MAPK signalling pathway leading to transcriptional changes [ 54], with one of the most robustly activated genes being the immediate early gene activity-regulated cytoskeletal-associated protein (ARC) [ 55].

In this study, we identified the most robustly activated face-sensitive areas in bilateral occipital-temporal cortices (i.e., AFP, aFFA, pFFA, OFA, pcSTS, pSTS) and systemically compared their regionally averaged activation and multivoxel activation patterns to 96 images from 16 object categories, including faces and non-faces.

The data suggest that the JNK pathway may be most robustly activated.

Unexpectedly, the amygdala was most robustly activated by suffering HWLs, followed by graphic HWLs and finally symbolic HWLs.

These findings from microarray analysis were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) analyses, with IL6, CXCL1 (human IL8 homolog), and CXCL5 being the most robustly activated genes (Fig 2E).

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We found that TALE activators robustly activated reporter genes when their binding sites were located within the promoter region.

Finally, we found that the majority of L6cc neurons in our sample were robustly activated after passive whisker touch, whereas most L6ct pyramids remained inactive (P = 0.07 at trend level).

LPA and S1P robustly activated Erk, but surprisingly both strongly suppressed Akt activation.

It is robustly activated by cytokines, bacterial and viral products and metabolic stresses.

Each is maintained at low basal levels, but is robustly activated by various stimuli, including cysteine-reactive small molecules (inducers).

Consistent with this, a recent study found that ER stress robustly activated mTORC1, which in turn induced apoptosis (Kato et al., 2012).

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