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The leech example highlights a critical aspect of co-option: it is most robustly studied within a phylogenetic framework because it is inherently historical.
The reduced dose enoxaparin is the most robustly studied LMWH regime in patients with renal dysfunction (see table).
Consequently, short-chain PFASs are some of the most robustly studied new chemicals introduced to the market, having undergone years of toxicity and environmental testing at the request of regulators.
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This paper provides a nidus around which the presented observations can be more robustly studied and clarified.
Both strands of miR-132, which was the miRNA most robustly downregulated in our study in serum, CSF and LCLs, have been shown to exert multiple functions in neuronal development and morphogenesis.
The most robustly regulated miRNAs in our study were miR-132-5p miR-132-5p miR-132-5p43-3p which were reduced to ~70% relative to healthy controls in both CSF and serum samples.
This was the most robustly associated gene in the study by Shah et al. The role of IGF1 signalling in cardiac hypertrophy is well established [ 51, 52] and the SNP lies immediately adjacent to a regulatory region recently identified by the ENCODE as being marked as transcriptional active in muscle cells, by Histone acetylation and DNAse 1 sensitivity [ 51].
The number of lawns mowed was the factor most robustly associated with seropositivity in our study, but the small number of seropositive landscapers limits the ability to detect other significant differences.
In this study, we identified the most robustly activated face-sensitive areas in bilateral occipital-temporal cortices (i.e., AFP, aFFA, pFFA, OFA, pcSTS, pSTS) and systemically compared their regionally averaged activation and multivoxel activation patterns to 96 images from 16 object categories, including faces and non-faces.
Consistent with this suggestion, this parietal positivity is the most robustly reproduced effect across different types of set switching studies.
Based on these data, we chose 50 as the read count that would most robustly identify IORs containing new sRNAs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com