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The most prominent defect in the dynein arm deficiency group was a translocation of central and/or peripheral microtubules.
The most prominent defect caused by Pik3c3 deletion is a severely reduced embryonic cell proliferation.
The most prominent defect observed in AP2 mutants is the presence of large diameter vesicles and vacuoles in the synapses of the α-μ2 adaptin double mutants.
The most prominent defect we observed was in the proximal part of the gonad arms, with fewer and often highly elongated oocytes present.
Discussion, "The most prominent defect observed in AP2 mutants is the presence of large diameter vesicles and vacuoles in the synapses of the α-μ2 adaptin double mutants.
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It is one of the most prominent defects and has a direct impact on road rideability.
Genetically, the involvement of mismatch repair in CSR has been well established in mice, with the most prominent defects observed in animals that also lack the uracil excision repair protein UNG2 [5].
Defects are observed at the cell membrane in some cases, but the most prominent defects are large vacuoles present in the synaptic varicosity.
We found that the most prominent prometaphase defect in CIN cells was spindle multipolarity and that CIN prometaphase cells exhibited multipolar spindles (Figure 1A) at frequencies that were significantly higher than those found in MIN cells (Figure 1B).
These results suggest that the initial steps in AMPA receptor endocytosis, rather than post-endocytic sorting, represent the most prominent trafficking defect accompanying loss of VAC14.
Congenital heart defects (CHDs) are the most prominent birth defects, with a prevalence of 4 to 10 per 1000 live births [ 1].
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