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So, impaired restriction modification may lead to the emergence of novel antibiotic-resistant strains, but also more pathogenic strains.
A population with more pathogenic strains and chemotypes can replace another.
hslJ transcript is up-regulated in more pathogenic strains of E. coli [ 24] and the protein is heat inducible [ 25].
This understanding will increase success in eradication for high-risk populations, while potentially maintaining the bacteria in low-risk populations, or specifically targeting more pathogenic strains.
It has been speculated that inter-subtype recombination may give rise to more pathogenic strains if genomic fragments from different subtypes join together in a better replicating virus, but no direct evidence for this scenario has so far been found.
Notably, WT littermates treated with AmBisome (3 mg/kg injected at days 0, 2, and 4 relative to viral inoculation) behaved identically to the Ifitm3−/− mice, experiencing a clinical course usually observed with more pathogenic strains of IAV and manifest by severe symptoms in conjunction with a weight loss exceeding 25% of their starting values.
Similar(54)
The putative agent of this new disease, identified in March 2003, is a novel and more pathogenic strain of the commonly occurring coronavirus (1, 2 ).
As more and more low pathogenic strains have been found to have 30-aa deletion in NSP2-coding region, this deletion will no longer be defined as the molecular marker of HP-PRRSV.
Because coccidioidomycosis is not uniformly distributed even in the area to which coccidioidomycosis is endemic, the higher rates likely reflect either a higher concentration of ambient spores or a strain that is more pathogenic than strains found elsewhere.
Encephalitis itself became a frequent complication of WNV fever in 1996 (11), which suggests the recent appearance of more pathogenic viral strains.
These strains provide a reservoir for the onward transfer of resistance alleles into more typically pathogenic strains and provide opportunities for the coalition of resistance and virulence determinants on plasmids as evidenced by the IncF replicons characterised in this study.
Related(20)
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