For cooperative lineage expansion with C D<3, non-mutator pathways, or mutator pathways with early mutator mutations, are more likely pathogenic mechanisms.
However, compelling available evidence suggests that further changes may occur, including possibly a switch for ANCA-associated vasculitides from a clinical and phenotype-based classification to one based more on pathogenic mechanisms.
The resulting abnormal local hemodynamics in the cervical spinal cord are also currently the more recognized pathogenic mechanism [ 3].
Although the prior study clearly showed prior infection confers resistance to superinfection/viremia with a more pathogenic virus, the mechanisms of this protection remain unclear.
Irrespective of the gene involved, neuropathological features argue for more complex underlying pathogenic mechanisms and are summarized in Table 1.
More insight into pathogenic mechanisms that influence the outcome of lower airway infection by S. aureus could help in the development of new (immunomodulating) therapies.
Based on this opinion, we assume that the present differential coexpression (DCE-) based human disease network should be more relevant to pathogenic mechanisms than the networks based on differential expression analysis (DEA).
However, some data suggest that the situation may be more complicated, and that pathogenic mechanisms beyond toxicity or abnormal interactions solely due to the polyQ-containing protein may contribute to polyQ expansion diseases.
Based on these findings, and to learn more about the differential pathogenic mechanisms mediated by Th1 and Th17 cells, we explored the cytotoxic potential of these distinct CD4+ T cell lineages.
More recently, evidence linking pathogenic mechanisms triggered by AβOs in the AD brain to mechanisms present in metabolic diseases has emerged [ 39, 63, 64].
