Sentence examples for more pathogenic variants from inspiring English sources

Identification of HEV serotypes in clinical cases is important for monitoring emergence of more pathogenic variants, epidemiological surveillance and investigating sources of infection.

Undeterred efficient dissemination of the pandemic (H1N1) 2009 virus among humans could allow opportunities to acquire adaptive mutations producing more pathogenic variants.

Sustained human-to-human transmission is a key requirement for pandemics and could result in the genesis of more pathogenic variants, as what happened with the 1918 pandemic virus (as reviewed in Reference 25).

As the resolution of genomic methods and experience in the field grow, it is likely both that more putatively pathogenic variants will emerge and that fewer will be deemed of 'unknown significance'.

None of the rapid progressors in the present study had viruses with sequence features associated with the presence of the more pathogenic X4 variant [7].

Thus, a disorder dominated by a heterogeneous model is one in which many relatively rare but more highly-penetrant pathogenic variants mediate risk for the disease in the affected population.

Significantly more unique reported pathogenic variants (4435) were identified using HGMD-DM, and 95%% of the individuals (10,531 out of 11,068) contain at least one HGMD-DM variant in an autosomal recessive gene.

Furthermore, in the aging, human colon somatic mtDNA mutations occur at random and are commonly nonsynonymous or frameshift mutations that are significantly more pathogenic than germline variants (Greaves et al., 2012).

Results were reported as positive if one or more pathogenic mutations or likely pathogenic variants were detected, negative if no variants and/or only likely benign variants were detected, or inconclusive if only variants of uncertain significance were detected.

On the basis of these findings, 2 different amino acids, D and E, might be considered polymorphic variants at position 222, and the potentially more pathogenic mutants or circulating variants would be G or N.

Our findings showed that PARK2 point mutations are more frequent than PINK1 pathogenic variants in our sample of Brazilian EOPD patients.