Sentence examples for molecular pathways implicated from inspiring English sources

High-throughput microarray gene expression profiling is an effective approach for the identification of candidate genes and associated molecular pathways implicated in a wide variety of biological processes or disease states.

The derivation of both normal MaSC [3], [5] and breast cancer stem cells [6], [7] should allow the delineation of molecular pathways implicated in breast cancer oncogenesis and prognostication applications [8].

Indeed, we and others have shown that extensive transcriptional changes occur in brain tissue from patients with AD [31], [33], and FTLD [16], [34], with specific molecular pathways implicated in both diseases (reviewed in [16]).

Among the categories enriched in the airway basal cell signature, a considerable number represented well-known signal transduction molecular pathways implicated in the regulation of tissue homeostasis and stem/progenitor cell function, including the NF-κB, Notch, EGFR, G protein-coupled receptor and VEGFR signaling pathways (Figure 4, left branch).

The molecular pathways implicated in the clearance of dying epithelial cells are being unraveled.

Therefore, a better understanding of the molecular pathways implicated in HoCC may yield new therapeutic targets for PDAC treatment.

PI 3-kinase pathway is pivotal in the regulation of EPC proliferation, recruitment and mobilization and its impairment in insulin resistance states seems to be a major molecular pathway implicated in reduced EPC counts and increased arterial stiffness [ 15].

Since NAD+ is a well-established axo-protectant in the context of Wallerian degeneration, this raises the question whether there might be a NAD+ controlled molecular pathway implicated in both Aβ-induced axon degeneration and Wallerian degeneration.

As shown, AMPK activation in normal cells or its loss of function in tumours can also be the molecular pathway implicated in the higher glucose uptake that occurs during the tumour metabolic shift known as the Warburg effect.

In this study we have used a gene expression microarray and a subsequent bioinformatic approach to identify new molecular mechanisms and pathways implicated in the expansion of pancreatic β-cells in the context of insulin resistance.

Many molecular pathways are implicated in carcinogenesis, and agents targeting these pathways have shown some efficacy in BTC cell lines [ 31, 32].