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Molecular components implicated in contact formation have been identified, but the mechanism of activation and the link between molecular interactions and cell response remain poorly understood due to the complexity and dynamics exhibited by whole cell-cell conjugates.
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Several components implicated as modulators of transdifferentiation of DD fibroblasts into myofibroblasts have been reported [ 59- 69].
Whether UNC93B1 interacts with other components implicated in trafficking of endosomal TLRs remains to be determined.
Casein kinases 1δ and ε are closely related clock components implicated in period determination.
Advances in experimental techniques and genetic studies have identified key molecular components that are implicated in the migration process.
Superimposition of T4SS structural/functional information over previously identified Rickettsia components implicate a functional Rickettsia T4SS.
Lymphocyte activation is a fundamental component implicated in the production of autoantibodies in SLE patients.
Several well studied proteins in this family have been implicated as important molecular components of chemoreception in insects, presumably effecting the transduction of pheromones or food chemostimulants to neuronal signals by transporting these ligands through the chemosensillar lymph to neuronal receptors [18].
While these are a subset of key molecular components, they nevertheless represent functional classes of mechanisms implicated in neuronal migration: guidance cues (GABA and the glial fiber), motility regulators (Lis1 and DCX), and stop signals (Reelin).
As a member of the MMP family, MMP-9 has been implicated to cancer progression by degradation of the molecular components of the basement membrane and extracellular matrix, liberating vascular endothelial cell growth factor (VEGF) from the extracellular matrix and therefore enabling angiogenesis, invasion and distant metastasis [ 8- 10].
And yet… there is an inescapable artifice that raises yet another barrier between us and our molecular components.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com