Sentence examples for molecular pathways altered from inspiring English sources

The recent identification of various molecular pathways altered in these tumours has significantly increased our knowledge of benign hepatocellular tumorigenesis.

However, during the last two decades there has been some progress on elucidating the genetic abnormalities present and molecular pathways altered in thymic tumors.

Our genomic dataset provides insights on the molecular pathways altered in the microenvironment of ICC and allows the identification of novel ICC biomarkers, as exemplified previously in Hepatology (PMID: 23775819).

She described cross-species transcriptome analysis to identify molecular pathways altered in NF1 tumors and guide molecular-targeted therapeutic strategies.

Moreover, the discovery of molecular pathways altered in cancer progression, as well as the identification of molecule-susceptible targets, would lead to the development of novel alternative therapies.

We describe a PGM framework based on factor graphs (Kschischang et al., 2001) that can integrate any number of genomic and functional genomic datasets to infer the molecular pathways altered in a patient sample.

Gene expression profiling and subsequent validations with quantitative real-time PCR (qRT-PCR) were conducted in order to identify the molecular targets and pathways altered during chemoresistance acquirement.

The ubiquitin-proteasome signaling [ 8, 10, 11], Ca2+-dependent proteolysis [ 12] and/or calpain-mediated proteolysis [ 6, 13, 14] have all been proposed to play a role, however the molecular and cellular pathways altered following β-AR agonist administration remain poorly understood [ 15].

In addition to the alterations on the core Hippo pathway, a number of other molecular pathways commonly altered in human carcinogenesis have the ability to cross talk with the Hippo pathway (reviewed by Irvine [33]).

In recent years, very important advances in molecular biology have allowed us to know which molecular pathways are altered in this tumor and to design drugs against abnormally expressed proteins in said pathways that have meant an important advance in survival for metastatic patients.

A comprehensive network-based understanding of molecular pathways abnormally altered in glioblastoma multiforme (GBM) is essential for developing effective therapeutic approaches for this deadly disease.