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The molecular pathways affected by addictive drugs are complex and inter-dependent on each other.
Gene expression profiling has been used for neurodegenerative disorders but mainly with the aim to identify molecular pathways affected by the disease process [8], [9].
Our founding expands the family of let-7 targets, and the identifying the molecular pathways affected in cancer could further reveal the mechanisms by which let-7a inhibits cell division.
To identify the major molecular pathways affected in each condition, Ingenuity Pathway Analysis (IPA) was performed.
First, we took an unsupervised approach and identified molecular pathways affected most at each time point.
Future studies should dissect the molecular pathways affected by this and other candidate tumor-suppressive snoRNAs.
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These data allowed us to significantly expand the profile of genetic variants that are potentially causative of ASD and to identify novel molecular pathways affecting ASD vulnerability in this cohort.
Furthermore, this integrative strategy was applied to specifically explore distinctive gene interactions of non-SMC condensin I complex, subunit G (NCAPG) and myostatin (GDF8), known modulators of pre- and postnatal growth that are only partially understood for their molecular pathways affecting differential body weight.
However, until now, the molecular pathway affected by excess levels of plasma corticosteroids was unknown.
'Chromatin organization' was the top molecular pathway affected by Hcy-thiolactone (Fig. 3a).
This was also supported by canonical pathway analysis using IPA, which identified TLR signalling as a molecular pathway affected by M. bovis infection.
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