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To assess the possible involvement of Group II mGlu receptors in the modulation of inhibition, we studied the effect of iontophoretic 1S,3R-ACPD in a condition-test protocol.
The uncinate fasciculus has also been directly implicated in the modulation of inhibition in patients with bvFTD [Hornberger et al., 2011].
Importantly, anaesthetic-induced modulation of inhibition may be influenced by the molecular identity of GABAARs (Belelli et al., 1996; Bonin & Orser, 2008), which are composed of five subunits drawn from a pool of 19 isoforms (Olsen & Sieghart, 2009).
For instance, while resting state evaluation is dominated by an inhibitory tone within M1, task-related evaluation shows a task specific modulation of inhibition (towards disinhibition) in healthy subjects associated with higher levels of skill acquisition.
Thus, it is unlikely that a simple model based on a modulation of inhibition in the cortical network could account for the properties of gamma synchronization we have observed in V1.
Similar(55)
Whereas various mechanisms that regulate the efficacy of synaptic inhibition have been identified (Olmos-Serrano et al., 2010; Cherubini, 2012), our knowledge regarding the modulation of tonic inhibition is far less complete.
In this study of normal subjects focusing on negative emotional processing, we hypothesized activity changes in specific frontal neocortical and limbic regions reflecting modulation of response inhibition by negative stimulus processing.
However, an abnormal modulation of recurrent inhibition of soleus has been observed during voluntary and postural contractions [12].
The dynamic modulation of interhemispheric inhibition may account for why healthy subjects' performance is typically explained by statistical facilitation, while there are also infrequent, yet clear, instances of coactivation in the healthy brain.
If there is such a modulation of local inhibition, it could also explain why APP mouse models are reported to have an increased risk for epileptic seizures, which would be expected by a downregulation of inhibitory or an upregulation of excitatory neuronal activity [34].
Parallel to our results at a molecular genetic level, these findings implicate the role of noradrenaline in the modulation of response inhibition.
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