Sentence examples for modulation of virulence from inspiring English sources
Understanding modulation of virulence thresholds could lend insight into disease outcome and aid in rational therapeutic and vaccine design.
The agent mediating this modulation of virulence gene expression is AIP.
The change of proportion of an sRNA over time in this medium may indicate its role in modulation of virulence factors.
Genes regulated by the group 2 sigma factor RpoS of E. coli and the group 3 sigma factor SigB of Bacillus subtilis, which are general stress-responsive sigma factors, encode various functions that are involved in the prevention and repair of DNA damage, cell morphology, modulation of virulence genes, osmoprotection, thermotolerance, glycogen synthesis, membranes, and the cell envelope.
In S. pneumoniae, regulation of carbohydrate-specific catabolic pathways as well as modulation of virulence factors by catabolite control protein A (CcpA) has been reported [ 30, 31], and the alteration in carbohydrate source and metabolic pathway leads to an increase in expression of these virulence factors [ 32, 33].
Fang et al. [ 24] demonstrated that gene disruption of a conidiation-associated gene (cag8) in M. anisopliae resulted in the lack of conidiation on agar plates and on infected insects reduced mycelial growth and decreased virulence, suggesting the involvement of cag8 in the modulation of conidiation, virulence, and hydrophobin synthesis in M. anisopliae.
Modulation of the virulence-associated loci might partially account for the attenuated virulence of the Δhfq::KmR mutant.
Taken together, these results suggest interference in early steps of macrophage infection either through modulation of yet unidentified virulence factors, blockade of ligand/receptor binding, suppression of ligand/receptor expression or due to direct non-specific toxic effects of the inhibitor.
The review aims to develop a conceptual framework for understanding modulation of EHEC's virulence program in response to the host.
Overall, these results support the concept that poly P kinases play an important role in the modulation of C. jejuni virulence by altering its OMC composition, leading to the modulation of IL-8 secretion by INT-407 cells.
There are thought to be sixteen two-component systems in S. aureus, including those that are responsible for the modulation of autolysis (ArlRS, LytRS), virulence (AgrAC, SaeRS) cell wall synthesis/drug resistance (GraRS, VraSR), and the sensing of external iron (HssRS) and oxygen (SrrRS) [12] [18].
