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These modifications increase the hydrophilicity, change the nanoscale topography and/or increase the abundance of functional groups on the surface, which can all modulate cell-surface interactions either through modulation of protein adsorption or by allowing modification with specific ligands.
Modulation of protein binding specificity is important for basic biology and for applied science.
Trx is used in ribonucleoide reduction, assimilatory sulfate reduction, in modulation of protein sulfhydryl groups, and refolding proteins.
Trx is used in refolding proteins ((Li and Churchich [1997]), in modulation of protein sulfhydryl groups (Buchanan et al. [1994]), and phage assembly (Russel and Mode [1986]).
Diseases like cancer can manifest themselves through changes in protein abundance, and microRNAs (miRNAs) play a key role in the modulation of protein quantity.
Our work demonstrates the feasibility of engineering Ca2+/calmodulin-mediated modulation of protein translocation and suggests that more natural analogs may exist.
The ultimate goal of using such molecules is the modulation of protein function through controlled interference with the underlying binding events.
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These interactions facilitate an 82° DNA bend around SRF and a modulation of protein-DNA contacts by each protein when compared to each of the binary DNA complexes.
Therefore, IF tyrosine phosphorylation does not appear to play an apparent role in IF network organization, which raises the possibility that this modification serves other functions that remain to be investigated such as the modulation of protein-protein interactions.
As a result, the modulation of protein-protein interactions by small organic molecules, so-called "protein-protein interaction disruptors" or PPIDs, offers innovative therapeutic avenues [ 7, 8].
In particular, DNA methylation at CpG dinucleotides is an important component of epigenetic gene expression regulation [ 4], resulting in modulation of protein-DNA interactions [ 5, 6].
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