Sentence examples for modulation of huntingtin from inspiring English sources

by modulation of huntingtin structure, and 2).

Cellular Hsp40 and Hsp70 modulate the aggregation behavior of Huntingtin.

Htt17 is of fundamental importance: it serves as a membrane anchor to control the localization of huntingtin, it modulates huntingtin's function through posttranslational modifications, and it controls the self-assembly of the amyloidogenic QN segment into oligomers and fibrils.

A structural basis for the apparent transition between normal and disease-causing expanded polyQ repeats of huntingtin is unknown.

They also created fruit flies that express the mutant version of huntingtin found in human patients.

The first 17 amino acids of Huntingtin protein (N17) play a crucial role in the protein's aggregation.

Proteolytic cleavage of huntingtin (Htt) is known to be a key event in the pathogenesis of Huntington's disease (HD).

While the interaction of N-terminal huntingtin with copper is a new finding, redox-mediated mechanisms of mutant huntingtin toxicity are compatible with established mechanisms of huntingtin toxicity such as dysregulation of axonal transport and transcription.

Proteolysis of huntingtin (Htt) plays a key role in the pathogenesis of Huntington's disease (HD).

A shorter half-life of huntingtin delayed aggregate formation, but increased cellular toxicity [25].

The acetylation of huntingtin at residue K444 promotes autophagic degradation of huntingtin itself [ 15].