Hsp70 is involved in cellular remodeling processes and in the modulation of apoptosis rate in teleosts [ 29], a process also modulated by Hsp90 in newt spermatogonia [ 30].
Dysregulation of apoptosis is among the Hallmarks of Cancer, and modulation of apoptosis holds promise as an effective therapeutic strategy for a range of malignancies.
Irrespective of all shortcomings, the future of modulation of apoptosis and cell cycle machinery for oncology therapy is quite exciting.
Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis.
CONCLUSIONS: These data suggest that calpain proteases play a pivotal role in warm ischemia-reperfusion injury of the rat liver through modulation of apoptosis and necrosis.
We investigated the p53-related functions of the hDkk-1 gene by studying its response to DNA damage and its modulation of apoptosis in human glioma cells.
Modulation of apoptosis is a known feature of RVFV [8].
Taken together, the modulation of apoptosis in human macrophages by S. aureus seems to be a novel occurrence.
The calpain family of cysteine proteases have been found to have an important role in a diverse number of cellular events ranging from regulation of the actin cytoskeleton (reviewed in [6]) to modulation of apoptosis [7].
Finally, PFD produced a modulation of apoptosis mediators in a chronic CsA-induced nephrotoxicity animal model.
Modulation of apoptosis may lead to aberrant hemopoiesis and neoplastic progression.
