Sentence examples for modulation of enhancer from inspiring English sources

This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.

To test the role of transcription in modulation of enhancer action, we used the yellow and white genes.

The presence of Brg1 at enhancers suggests that Brg1 regulates transcriptional activation during mesoderm induction through modulation of enhancer activity.

In order to evaluate the possible role of intergenic transcription in modulation of enhancer action, we have examined the effect of transcription on the activity of yellow and white gene enhancers using transgenic reporter systems.

Interestingly, Bim is upregulated as a means to eliminate auto-reactive B cells and to prevent autoimmune disease, suggesting a rationale for precise modulation of enhancer activity at the Bim locus by TRIM33 to regulate adaptive immunity (Bouillet et al., 1999; Enders et al., 2003).

We hypothesized that differential gene expression correlates with epigenetic modulation of proximal enhancers.

Remarkably, their finding is the best proof to date that a controlled combinatorial modulation of barriers and enhancers can advance pluripotent reprogramming with 100%% efficiency.

As a first step towards deciphering the mechanisms that underlie enhancer clustering, we next asked whether modulation of the epigenome would change the Sox2 enhancer clustering behavior in single live cells.

By contrast, the usefulness of simple and high-throughput screening tests for the detection of cognition enhancers might be restricted to advanced drug-finding programs that are guided by evidence of the modulation of neurocognitive relationships by cognition enhancers and that are informed by iterative preclinical clinical cross-validation of research approaches.

Our previous ChIP-seq study of SRF in primary macrophages indicated a critical role of SRF in promoting hematopoietic-cell-restricted gene expression through binding at distal enhancers, while modulation of generally expressed genes occurred at promoters [ 26].

Having thus defined these four modes of nucleosome remodeling, we set out to test whether they demonstrate functionally distinct relationships between GR binding, nucleosome remodeling, enhancer activation, and modulation of gene expression.