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This resetting of dysfunctional brain networks by therapeutic DBS is mediated by white matter stimulation and modulation of network dynamics by adjusting local field potential.
The mechanisms underlying this effect involve, in addition to mGluR5-mediation of intracellular calcium concentrations, regulation of mGluR1 receptor expression and the modulation of network activity in theta and gamma frequency ranges in the dentate gyrus.
Optogenetic modulation of network activity in vitro.
Because we were primarily interested in the relationship between rMDD and the emotional modulation of network connectivity, we used a first stage of DCM modeling to identify the most likely network.
We here investigated the dopaminergic modulation of network dynamics underlying basic motor performance, i.e. finger tapping, and higher motor control, i.e. internally and externally cued movement preparation and selection.
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Two generally hypothesized mechanisms of action are that deep brain stimulation creates a functional lesion via inhibition within the stimulated region and, alternatively, that deep brain stimulation activates the neuronal network connected to the stimulated region, leading to modulation of pathological network activity (Johnson et al., 2008).
Further, we found that while the relative strength of functional network connections were differentially modulated by task demands in adults, there was no such modulation of this network in either older or younger children.
The finding of both hyperactivation and hypoactivation in the ventral network in ADHD [Cortese et al., 2012] suggests that difficulties may lie in the top-down modulation of this network rather than an impaired orienting response per se.
However, this is the first ever report demonstrating the intricate modulation of genetic network affected by NPs.
Proposed mechanisms of action include short and long-term local effects of stimulation at the neuronal level, to modulation of neural network activity.
Decreasing the thickness of the matrix also results in comparable modulation of the network architecture, supporting the boundary effect is mediated mechanically.
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variation of network
preparation of network
alteration of network
adjustment of network
manipulation of network
diversity of network
modulation of pHi
modulation of virus host
modulation of scFv
modulation of receptor
modulation of brain
modulation of pain
modulation of inflammation
modulation of activity
modulation of calcineurin
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