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Immunofluorescence (IF) and scanning electron microscopy (SEM) were performed to compare the modulation in cell morphologies and characteristics.

Osteoblast cells were cultured on different nanoporous surfaces having different pore diameter, for days 1 and 3, and the modulation in cell morphology was observed with the SEM.

Highlighting the role of epigenetic modulation in cell fate determination and conversion, Takeuchi and Bruneau directed ectopic differentiation of embryonic mouse mesoderm into beating cardiomyocytes using transient transfection of the cardiac transcription factor Gata4 and the cardiac specific chromatin remodeling complex subunit, Baf60c (Takeuchi and Bruneau, 2009).

Taken together, our experimental results provided evidence for a dynamic regulation of meristem domains, which is correlated with a modulation in cell behavior.

In order to assess the extent of modulation in cell cycle gene expression during chronic infection, PCR arrays of 84 cell cycle genes were performed in RNA samples separately pooled from early HCV, advanced HCV and commercial preparation of human normal liver RNA.

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Other independent groups have conducted experiments that confirm gene modulation in cells incubated with homeopathic dilutions of different substances.

To date, however, all these important insights are derived from studies carried out in neuronal cells, and the implication of α-synuclein in autophagy modulation in cells other than neurons has not been investigated yet.

The rather modest observed variation in cell number at Day 10 may reflect modulations in cell cycle kinetics (duration of progression through each of the cell cycle stages), as well as the balance between cell survival and cell death.

To ensure that the dietary fat-induced modulations in cell cycle-related processes reflected proliferation of enterocytes and not immune cells (see below), we performed immunohistochemistry on the distal part of the small intestine.

Although this phenomenon is not readily interpretable, the above differential effect of azacitidine suggests the presence of distinct mechanisms of DNA methylation modulation in these cell types, such as targeting cell-type-specific regulatory elements important for CD25 expression.

In our previous report, we demonstrated that a low dose lovastatin (equivalent to cardiovascular dose) induced G1 phase cell cycle arrest and cell senescence via RhoA modulation in cancer cells [ 16].

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