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Our initial method to measure modulation in gene expression was done using scatter plot analysis.
A 4-fold cutoff threshold was used to determine modulation in gene expression.
In addition, the second pair of contrasting genotypes showed a similar modulation in gene expression.
This robust modulation in gene expression by both Mtb strains indicated an early dynamic reprogramming of host cellular machinery upon infection of BMM by Mtb.
Other TFs that have been shown to have a regulatory role, such as HAP2/3 and AreA, showed no significant modulation in gene expression in any condition (log2 > 1 and P <0.05).
Although we were cautious to ensure that any exposure-associated alterations in DNA methylation were not merely due to changes in the ratios of blood cells by including blood cell proportions as key covariates in all of our models (explained in Methods)—we lack the ability to link these epigenetic marks to any appreciable modulation in gene expression in these blood cells.
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Analyses of DNA methylation and histone modulation in genes associated with AD from patients' prefrontal cortex and lymphocytes have revealed abnormal profiles [33].
However, slight modifications were introduced to integrate in the methodology the notions of: (i) "modulation" in genes transcription; and (ii) activation of genetic regulators (switch from "off" to "on") according to the presence of external metabolite pools.
However, in the case of red QDs treatment, a high modulation in genes related to transport (almost 4-fold higher than that observed with green QDs) and a moderate effect on genes involved in glycolysis and tricarboxylic acid cycle were observed.
The diversity of insertion sites produces many opportunities for adaptive modulations in gene expression.
MiRNAs regulation typically allows such subtle modulations in gene expression dosage.
More suggestions(15)
modulation in pressure
modulation in pain
modulation in signal
modulation in term
modulation in multiuser
modulation in high-frequency
modulation in multi-frequency
modulation in electron
modulation in membrane
modulation in sleep
modulation in accordance
modulation in plant
modulation in event
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modulation in response
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