Sentence examples for transformation in cell from inspiring English sources

These cells have undergone spontaneous transformation in cell culture and transitioned from non-tumorigenic to intermediate and aggressive, malignant phenotypes.

The syngeneic mouse ovarian surface epithelial (MOSE) cells, derived from the C57BL6 mice, have undergone spontaneous transformation in cell culture.

Importantly, ectopic expression of MGA can block Myc-dependent cellular transformation in cell culture assays [43], implying that it may itself provide a tumor suppressor function in vivo.

Src is a non-receptor tyrosine kinase that can cause cellular transformation in cell culture and tumor formation in animals if its activity becomes elevated.

Overexpression of HER2 protein drives malignant transformation in cell culture and transgenic mouse models [ 4, 5].

Teashirt also controls a dramatic transformation in cell morphology, from cuboidal to the eponymous stellate shape, during metamorphosis.

Focusing on simian virus 40 (SV40) and mechanisms of malignant transformation in cells, Jaenisch moved toward using mice as models for cancer research and became interested in the increased susceptibility to cancer exhibited by certain cell types.

Based on this feature, we have termed transformation in cell-mixed culture as cell-to-cell transformation, in which cell-to-cell supply of plasmid DNA during culture plays an important part.

This result indicates that purified plasmid is not used for natural transformation in liquid culture, suggesting that a specific state of plasmid DNA that is released from co-cultured donor cells is required for efficient lateral plasmid transformation in cell-mixed culture.

These data show that PID expression strongly inhibited tumor formation in the NF2 xenograft model, suggesting that Group I Paks are required for transformation in cells that have lost Merlin function.

The PA42-C4 line did not show growth in soft agar after 4 weeks in culture, demonstrating no malignant transformation in cells).