Sentence examples for modulating the subcellular from inspiring English sources

Since Resveratrol blocked Akt activation it was essential to demonstrate if Akt activation pathway was involved in modulating the subcellular distribution and activation of HSF1, the transcription factor responsible for expression of hsp70 gene.

In work unrelated to Pin1, Tsai et al proposed a model wherein the phosphorylation state of APP Thr668 would be pivotal in modulating the subcellular distribution of APP and generation of Aβ [4] and/or the amyloidogenic γ-secretase cleavage of APP CTFs [19].

Mattison and Ota showed that Ptp2p is a nuclear tether for Hog1p and Ptp3p is a cytoplasmic anchor, thus modulating the subcellular localization of Hog1p [ 51].

These results suggest a role for HK2 in regulating Bcl-xL expression and apoptosis, likely through modulating the subcellular localization of hnRNP A1.

In order to elucidate whether such a MST-FOXO signaling mechanism contributes to modulating the subcellular localization and activity of FOXO3a during the pathogenic process of neurogenic muscle atrophy, we examined the phosphorylation status of FOXO3a at Ser207 in both WT and MST1 deficient TA muscles undergoing atrophy.

Indeed, cell shape and matrix rigidity modulate the subcellular localization of YAP and TAZ and cytoskeletal destabilization and inhibition of cell contractility inactivate YAP and TAZ [168].

We examined whether Sema3E/Plexin-D1 signal modulated the subcellular localization of Snail1 in OEC cells.

The above studies suggest that mDpy-30 and its interacting proteins modulate the subcellular distribution and expression of β1 integrin, as well as cell adhesion/migration.

Many of the changes observed in the present study are also found in human ovarian cancer and therefore validate the use of our model for future mechanistic studies to further define how cytoskeletal organization modulates the subcellular localization of cancer promoting signaling pathways.

We propose a model in which the role of oestrogen is to modulate the subcellular localization of SOX9 (Fig. 5).

DMOG modulated the subcellular localization of Rac-1 and activation of its downstream target p21-activated kinase (PAK).