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We found that cell shape regulates αSMA expression in part by controlling the subcellular localization of myocardin related transcription factor (MRTF -A (Figure 2B).
These results suggest that Numb may regulate EMT by controlling the subcellular localization of polarity proteins.
Despite the importance of Cdk2 localization in regulating cell proliferation, little is known about the mechanisms controlling the subcellular targeting of Cdk2.
Altogether, this analysis suggests that the Tn-regulating genes are acting at the Golgi level, perhaps part of a regulatory network controlling the subcellular localisation of GalNAc-Ts.
Additionally, many of the factors identified in the screen have been previously implicated in controlling the subcellular distributions and translation of maternal mRNAs in the oocyte and early embryo.
The intrinsic ∼24 h periodicity of the clock is regulated in large part by controlling the subcellular localization and stability of PER CRY complexes through the opposing activity of kinases, phosphatases, and ubiquitin E3 ligases.
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The NTD controls the subcellular distribution of DNMT1 during the cell cycle and its enzymatic activity.
Recently, we discovered that oxidative stress and antioxidants control the subcellular distribution of PML.
In our previous study, we demonstrated that the C-terminus of Dcr1 functions to control the subcellular localization of Dcr1.
Regardless of the underlying mechanism, in this study we show that BICDR-1 controls the subcellular distribution of Rab6 secretory vesicles.
Specific protein-protein interactions can thereby control the subcellular localization, enzymatic activity and the assembly of multi-protein complexes, thus allowing the flow of information through signaling pathways.
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