Sentence examples for modulating the therapeutic from inspiring English sources

MSC is highly effective in modulating the therapeutic index of irinotecan.

Additional data suggest that the glutamatergic system and AMPA receptors specifically, have an important role in modulating the therapeutic effects of mood stabilizers.

Several natural and (semi) synthetic chalcones deserve the credit of being potential candidates that act by modulating the therapeutic targets PPAR-γ, DPP-4, α-glucosidase, PTP1B, aldose reductase, and stimulate insulin secretion and tissue sensitivity.

As CXCL12 is abundantly expressed by stromal cells (Matsuo et al, 2009), this could be an exemplary example for the role of tumour microenvironment interaction in modulating the therapeutic response.

To date, various types of nanomaterials have been incorporated with stem cells to control cell fate, modulate the therapeutic behavior of stem cells, and make them more suitable for cardiac repair.

Extension of this line of thought would suggest that differential levels of zinc deficiency in individuals or populations within developing countries might modulate the therapeutic benefits attributable to zinc.

Does an intrapulmonary P. aeruginosa infection promote a neutralizing antibody response in the lung? 2. Does prior pulmonary exposure to P. aeruginosa infection modulate the therapeutic effects of IL13-PE? 3. Do circulating IL13-PE-specific antibodies neutralize the therapeutic effects of intranasally delivered IL13-PE during pulmonary fibrosis?

Identification and development of drugs that can effectively modulate the therapeutic efficacy and toxicity of chemotherapy remain an unmet challenge.

Human Fcγ receptors mediate effector functions of immunoglobulin G (IgG) antibodies and may modulate the therapeutic efficacy of all biological substances containing IgG-Fc parts.

However, further exploration of the contribution of genetic, environmental, and physiological factors in the development resistance to endogenous A β-antibody is needed in order to optimize and modulate the therapeutic strategies currently being developed.

Previous reports from this laboratory have clearly demonstrated that MSC can synergistically modulate the therapeutic selectivity and efficacy of chemotherapeutic agents with different mechanisms of action in variety of xenograft models when used before and during treatment (Cao et al, 2004).