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ROS induces cell death by modulating cell signaling pathways.
In conclusion, PTPR alterations collectively play an important role in modulating cell signaling, leading to effects on proliferation, apoptosis, survival, migration, invasion, and metastasis.
Additionally, MTA inhibits protein methylation, modulating cell signaling and protein expression [ 9, 16, 17].
It is widely known that MTA inhibits methyltransferase enzymatic reactions and interferes with cellular pathways modulating cell signaling and protein expression [ 5, 14, 16, 17].
Furthermore, although the flavonoids are often described as nontoxic compounds, some studies have demonstrated that they are capable of influencing a variety of cellular functions by modulating cell signaling and proliferation [ 9] and under certain conditions may exhibit toxic activity by production of free radical species [ 10].
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As dSdc can act to modulate cell signaling, alternative alleles could be highly sensitive to different levels of signaling molecules that naturally occur between the sexes.
The WNV NS proteins can also modulate cell signaling and immune responses [ 58– 67].
MPO can also modulate cell signaling and inflammatory responses independently of its enzymatic activity.
More recently, several GST isoenzymes have been shown to modulate cell signaling pathways that control animal cell proliferation and cell death (apoptosis) [ 5, 13].
At low concentrations, ROS appear to modulate cell signaling chiefly by modifying key thiol groups on proteins that possess regulatory functions [26 28].
Arsenic has been shown to modulate cell signaling by inducing mitogen-activated protein kinases to change gene expression (Beyersmann 2002; Yang and Frenkel 2002).
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