Sentence examples for modulating cell death from inspiring English sources

To test the role of each pathway in modulating cell death, we applied kinase signaling inhibitors and then measured changes in cell death and viral reactivation following 48 hours of CD3/CD28 stimulation.

Finally, targeting the specific targeting of cholesterol to mitochondria may be an additional approach of potential benefit in cancer treatment by modulating cell death and chemotherapy resistance.

Although in the serum of patients affected by acute myocardial infarction (AMI) several cytokines, including those belonging to the TNF family members, are known to be elevated [1], only limited information is available on the role of TNF family members in modulating cell death after myocardial ischemia [2] [4].

The mitochondrion is a widely used target by many pathogens for modulating cell death.

Collectively, our results implicate iron in modulating cell death in a Ras- and MAPK-dependent manner in ovarian cancer cells.

For this reason, the therapeutic potential in modulating cell death in human disease remains an enormously plausible yet unrealized opportunity.

Inhibition of p38 selectively modulates cell death in infected cells following stimulation with CD3/CD28.

We concluded that TNZ is genotoxic, cytotoxic and is able to modulate cell death through apoptotic mechanisms in the experimental design employed.

Disruption of heterodimerizations by small-molecule inhibitors could be used to modulate cell death in both cancer (to increase apoptosis) and degenerative disorders (to decrease apoptosis), and assays are necessary to screen compound libraries.

Here, we demonstrate that the central mechanisms of PEI architecture- and size-dependent perturbations of integrated cellular metabolomics involve destabilization of plasma membrane and mitochondrial membranes with consequences on mitochondrial oxidative phosphorylation (OXPHOS), glycolytic flux and redox homeostasis that ultimately modulate cell death.

Most importantly, disruption of mitochondrial fission can inhibit Reaper and Hid-induced cell death, suggesting that alterations in mitochondrial dynamics can modulate cell death in fly cells.